Academic staff

Patrice LE PAPE

Full Professor of Parasitology and medical Mycology, University of Nantes, France Director of the research team EA 1155 IICiMed, University of Nantes, France Head of the department of Parasitology and medical Mycology, Nantes University Hospital, France.

Contact details

Service de Parasitologie et Mycologie médicales UFR des Sciences Pharmaceutiques 1,rue Gaston Veil 44035 Nantes Cedex 1 Service de Parasitologie, Mycologie médicale et Immunologie parasitaire Institut de Biologie- CHU de Nantes 9,quai Moncousu 44000 Nantes Cedex 1

Phone
0240412867 (n° interne : 312867)
Email
Patrice.Le-Pape@univ-nantes.fr

Taught academic discipline(s)

Parasitology and Medical mycology

Research topics

The group IICiMed has an expertise on host-fungi interaction and antifungal drug resistance in order to identify potential targets and synthetize drug candidates in fungal diseases. Numerous fungal mechanisms of resistance have been characterized as overexpression of efflux pumps mRNA, Erg11 mutations and tandem repeats in Erg11 gene promoter. The team has recently developed a novel and original human in vitro model of fungal granuloma evidencing mechanism leading to controlled or persistent Infection outcomes. The team is also involved in investigations on innovative carrier for the delivery of antifungal drugs as imprinted textiles nanocarrier and antibodies. In close collaboration with clinical teams and many international teams, EA 1155 maintains a large bank of clinical isolates. More recently, the One Health approach is developed to study environmental resistance in Aspergillus and yeasts.

Activities / Resume

Patrice Le Pape have contributed to more than 120 publications and book chapters and 8 patents. He is founder of Mycobiotics start-up devoted to diagnosis in medical mycology. He is co-founder and past-President (2012-2015) of the french national consortium for antiparasitic and antifungal chemotherapy (CaPF) including 26 french research laboratories from Universities, INSERM, CNRS, INRA. He is Board Member of the French Society of Medical Mycology.