Academic staff

Pascal MARCHAND

Professor
Département 5 - Élaboration, Évaluation du Médicament

Contact details

Head of Medicinal Chemistry Department & Deputy director EA1155 - IICiMed Institut de Recherche en Santé 2 Université de Nantes 22 Boulevard Bénoni Goullin 44200 Nantes, France

Office
226 (Bias - Teaching)
Phone
0253484133 (n° interne : 334133)
Fax
0240412876
Office 2
102 (IRS2 - Research)
Phone 2
0253009155 (n° interne : 329155)
Email
Pascal.Marchand@univ-nantes.fr
Personal Website
http://www.iicimed.univ-nantes.fr

Taught academic discipline(s)

Organic Chemistry, Medicinal Chemistry, Drug Design, Spectral Methods

Research topics

Design, synthesis and biological evaluation of heterocyclic compounds for therapeutic purposes (mycology, parasitology and cancer). Inhibitors of kinase signaling pathways. ADMET properties of molecules of biological interest. Microwave-assisted organic chemistry.

Activities / Resume

Academic qualifications    

Medicinal Chemistry department, EA1155 - IICiMed, Faculty of Pharmacy, Nantes.

September 2013: Professor of Organic Chemistry (1st class September 2016)

June 2007: Habilitation in Medicinal Chemistry - Design, synthesis and biological evaluation of azaheterocyclic compounds

September 2001: Assistant Professor in Organic Chemistry

January 2000-August 2001: Lecturer in Organic Chemistry
 
November 1999: PhD Thesis in Medicinal Chemistry - Synthesis and biological evaluation of indole derivatives as immunosuppressive and anti-cancer agents

June 1996: Master's degree in Pharmacochemistry

Involvement in postgraduate education/supervision/examination                    

PhD thesis supervisions (16): industry collaborations (Æterna Zentaris-Germany and Servier-France) and academic collaborations (Parasitology and Medical Mycology department of IICiMed team and international joint supervisions)

Felipe NEVES COUTINHO (Cotutelle supervision at 50%) - Design, synthesis and biological evaluation of bicyclic isoxazole and isoxazoline derivatives – defense planned on March 2022. Co-supervision: Prof. Teresinha Gonçalves da Silva, Recife - Federal University of Pernambuco, Brazil.

Celia ROUGES (Co-supervision at 50%) - Interaction Hsp90 / Sba1 new target for the treatment of invasive candidiasis – defense planned on November 2021. Thesis supervisor: Prof. Patrice Le Pape.

Martha Laura Hernández Carrillo (Cotutelle supervision at 50%) – Synthesis, structural characterization of new amino-ethers of three lignans isolated from Larrea tridentata and determination of their activity against resistant bacteria – defense planned on September 2021. Co-supervision: Prof. María del Rayo Camacho Corona, Monterrey – Autonomous University of Nuevo León, Mexico.

Guillermo Núñez-Mojica (Cotutelle supervision at 50%) – Isolation, structural characterization and assessment of the antibacterial activity of constituents of Solanum chrisotrichum Schldl. and their derivatives – defense planned on January 2021. Co-supervision: Prof. María del Rayo Camacho Corona, Monterrey – Autonomous University of Nuevo León, Mexico.
  .

Masters 2 (MSc) (13)

Postdoctoral researchers (8)

55 international publications and 4 international patents (h Index: 16)

Recent publications and patent
 

International research collaborations (see: Other information)

PHC ULYSSES 2020 Programme - Ireland
CAPES-COFECUB 2015/2018 Programme - Brazil

Additional informations

International research collaborations

PHC ULYSSES 2020 Programme - Ireland
Campus France, responsible for the management of Hubert Curien Partnership (PHC) has selected the project ULYSSES 2020 filed jointly by the Department of Medicinal Chemistry of IICiMed team (Prof. Pascal Marchand, University of Nantes) and "Department of Chemistry and ABCRF "(Dr Florence McCarthy, University College Cork, Ireland). This ongoing collaboration is a work of Medicinal Chemistry in the field of Medical Mycology that led to the mobility of students and project managers between the two sites.
 
CAPES-COFECUB 2015/2018 Programme - Brazil
The French Committee for the Evaluation of Academic and Scientific Cooperation with Brazil (COFECUB) in partnership with the CAPES (Coordenação de Aperfeiçoamento do Pessoal de Nível Superior, the Federal Agency of Support and Evaluation of Postgraduate Education) has selected the project submitted jointly by the team IICiMed (Prof. Pascal Marchand, University of Nantes) and the Department of Antibiotics, Biological Sciences Center (Prof. Teresinha Silva, Federal University of Pernambuco, Recife, Brazil). The research program, with duration of 4 years, entitled "Discovery of novel thiazolinones, thiazolidinones and quinones for the treatment of infectious diseases and cancer" is achieved through the mobility of researchers, PhD students and postdoctoral researchers, chemists and biologists.

Professional activities (member of committees/research clusters etc.)

Member of Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A) and President from September 2017.

www.gp2a.org